難治性の肝・胆道疾患に関する調査研究　厚生労働省難治性疾患政策研究事業

研究の成果

原発性硬化性胆管炎（PSC）

最終更新日：2022年6月2日
  1. Sato T, Kogure H, Nakai Y, Ishigaki K, Hakuta R, Saito K, Saito T, Takahara N, Hamada T, Mizuno S, Yamada A, Tada M, Isayama H, Koike K. Double-balloon endoscopy-assisted treatment of hepaticojejunostomy anastomotic strictures and predictive factors for treatment success. Surg Endosc. 2020 Apr;34(4):1612-1620. https://pubmed.ncbi.nlm.nih.gov/31218422/
  2. Hakuta R, Hamada T, Nakai Y, Oyama H, Kanai S, Suzuki T, Sato T, Ishigaki K, Saito K, Saito T, Takahara N, Mizuno S, Kogure H, Watadani T, Tsujino T, Tada M, Abe O, Isayama H, Koike K. Natural history of asymptomatic bile duct stones and association of endoscopic treatment with clinical outcomes. J Gastroenterol. 2020 Jan;55(1):78-85. https://pubmed.ncbi.nlm.nih.gov/31473828/
  3. Nakai Y, Sato T, Hakuta R, Ishigaki K, Saito K, Saito T, Takahara N, Hamada T, Mizuno S, Kogure H, Tada M, Isayama H, Koike K. Management of Difficult Bile Duct Stones by Large Balloon, Cholangioscopy, Enteroscopy and Endosonography. Gut Liver. 2020 May 15;14(3):297-305. https://pubmed.ncbi.nlm.nih.gov/31581389/
  4. Nakai Y, Isayama H, Wang HP, Rerknimitr R, Khor C, Yasuda I, Kogure H, Moon JH, Lau J, Lakhtakia S, Ratanachu-Ek T, Seo DW, Lee DK, Makmun D, Dy F, Liao WC, Draganov PV, Almadi M, Irisawa A, Katanuma A, Kitano M, Ryozawa S, Fujisawa T, Wallace MB, Itoi T, Devereaux B. International consensus statements for endoscopic management of distal biliary stricture. J Gastroenterol Hepatol. 2020 Jun;35(6):967-979. https://pubmed.ncbi.nlm.nih.gov/31802537/
  5. Sato T, Kogure H, Nakai Y, Ishigaki K, Hakuta R, Saito K, Saito T, Takahara N, Hamada T, Mizuno S, Tada M, Isayama H, Koike K. A prospective study of fully covered metal stents for different types of refractory benign biliary strictures. Endoscopy. 2020 May;52(5):368-376. https://pubmed.ncbi.nlm.nih.gov/32092770/
  6. Ishigaki K, Hamada T, Nakai Y, Isayama H, Sato T, Hakuta R, Saito K, Saito T, Takahara N, Mizuno S, Kogure H, Ito Y, Yagioka H, Matsubara S, Akiyama D, Mohri D, Tada M, Koike K. Retrospective Comparative Study of Side-by-Side and Stent-in-Stent Metal Stent Placement for Hilar Malignant Biliary Obstruction. Dig Endosc. 2021 Jan;33(1):170-178. https://pubmed.ncbi.nlm.nih.gov/32107675/
  7. Hamada T, Nakai Y, Isayama H, Koike K. Antireflux metal stent for biliary obstruction: Any benefits? Dig Endosc. 2021 Mar;33(3):310-320. https://pubmed.ncbi.nlm.nih.gov/32250476/
  8. Matsubara S, Isayama H, Nakai Y, Kawakubo K, Yamamoto N, Saito K, Saito T, Takahara N, Mizuno S, Kogure H, Ishizawa T, Arita J, Hasegawa K, Koike K. Endoscopic ultrasound-guided gallbladder drainage with a combined internal and external drainage tubes for acute cholecystitis. J Gastroenterol Hepatol. 2020 Oct;35(10):1821-1827. https://pubmed.ncbi.nlm.nih.gov/32267555/
  9. Takahara N, Nakai Y, Saito K, Sasaki T, Suzuki Y, Inokuma A, Oyama H, Kanai S, Suzuki T, Sato T, Hakuta R, Ishigaki K, Saito T, Hamada T, Mizuno S, Kogure H, Tada M, Isayama H, Koike K. The impact of age and comorbidity in advanced or recurrent biliary tract cancer receiving palliative chemotherapy. J Gastroenterol Hepatol. 2020 Oct;35(10):1828-1835. https://pubmed.ncbi.nlm.nih.gov/32267557/
  10. Nakai Y, Sato T, Hakuta R, Ishigaki K, Saito K, Saito T, Takahara N, Hamada T, Mizuno S, Kogure H, Nogchi K, Ito Y, Isayama H, Koike K. Long-term outcomes of a long, partially covered metal stent for EUS-guided hepaticogastrostomy in patients with malignant biliary obstruction (with video). Gastrointest Endosc. 2020 Sep;92(3):623-631.e1. https://pubmed.ncbi.nlm.nih.gov/32278705/
  11. Kogure H, Kawahata S, Mukai T, Doi S, Iwashita T, Ban T, Ito Y, Kawakami H, Hayashi T, Sasahira N, Kubota K, Togawa O, Kato H, Okabe Y, Matsubara S, Yagioka H, Saito T, Nakai Y, Isayama H. Multicenter randomized trial of endoscopic papillary large balloon dilation without sphincterotomy versus endoscopic sphincterotomy for removal of bile duct stones: MARVELOUS trial. Endoscopy. 2020 Sep;52(9):736-744. https://pubmed.ncbi.nlm.nih.gov/32299114/
  12. Fujisawa T, Ushio M, Takahashi S, Yamagata W, Takasaki Y, Suzuki A, Okawa Y, Ochiai K, Tomishima K, Ishii S, Saito H, Isayama H. Role of Peroral Cholangioscopy in the Diagnosis of Primary Sclerosing Cholangitis. Diagnostics (Basel). 2020 Apr 29;10(5):268. https://pubmed.ncbi.nlm.nih.gov/32365686/
  13. Sato T, Kogure H, Nakai Y, Kanai S, Ishigaki K, Hakuta R, Saito K, Saito T, Takahara N, Hamada T, Mizuno S, Yamada A, Isayama H, Koike K. Endoscopic treatment of hepaticojejunostomy anastomotic strictures using fully-covered metal stents. Dig Endosc. 2021 Mar;33(3):451-457. https://pubmed.ncbi.nlm.nih.gov/32559351/
  14. Ishii S, Fujisawa T, Ushio M, Takahashi S, Yamagata W, Takasaki Y, Suzuki A, Okawa Y, Ochiai K, Tomishima K, Kanazawa R, Saito H, Shiina S, Isayama H. Evaluation of the safety and efficacy of minimal endoscopic sphincterotomy followed by papillary balloon dilation for the removal of common bile duct stones. Saudi J Gastroenterol. 2020 Jul 21;26(6):344-50. https://pubmed.ncbi.nlm.nih.gov/32719239/
  15. Kitano M, Gress TM, Garg PK, Itoi T, Irisawa A, Isayama H, Kanno A, Takase K, Levy M, Yasuda I, Lévy P, Isaji S, Fernandez-Del Castillo C, Drewes AM, Sheel ARG, Neoptolemos JP, Shimosegawa T, Boermeester M, Wilcox CM, Whitcomb DC. International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club. Pancreatology. 2020 Sep;20(6):1045-1055. https://pubmed.ncbi.nlm.nih.gov/32792253/
  16. Ishii S, Isayama H, Ushio M, Takahashi S, Yamagata W, Takasaki Y, Suzuki A, Ochiai K, Tomishima K, Kanazawa R, Saito H, Fujisawa T, Shiina S. Best Procedure for the Management of Common Bile Duct Stones via the Papilla: Literature Review and Analysis of Procedural Efficacy and Safety. J Clin Med. 2020 Nov 25;9(12):3808. https://pubmed.ncbi.nlm.nih.gov/33255554/
  17. Nagino M, Hirano S, Yoshitomi H, Aoki T, Uesaka K, Unno M, Ebata T, Konishi M, Sano K, Shimada K, Shimizu H, Higuchi R, Wakai T, Isayama H, Okusaka T, Tsuyuguchi T, Hirooka Y, Furuse J, Maguchi H, Suzuki K, Yamazaki H, Kijima H, Yanagisawa A, Yoshida M, Yokoyama Y, Mizuno T, Endo I. Clinical practice guidelines for the management of biliary tract cancers 2019: The 3rd English edition. J Hepatobiliary Pancreat Sci. 2021 Jan;28(1):26-54. https://pubmed.ncbi.nlm.nih.gov/33259690/
  18. Nakanuma Y, Uesaka K, Kakuda Y, Sugino T, Kubota K, Furukawa T, Fukumura Y, Isayama H, Terada T. Intraductal Papillary Neoplasm of Bile Duct: Updated Clinicopathological Characteristics and Molecular and Genetic Alterations. J Clin Med. 2020 Dec 9;9(12):3991. https://pubmed.ncbi.nlm.nih.gov/33317146/
  19. Ishii S, Fujisawa T, Isayama H, Asahara S, Ogiwara S, Okubo H, Yamagata H, Ushio M, Takahashi S, Okawa H, Yamagata W, Okawa Y, Suzuki A, Takasaki Y, Ochiai K, Tomishima K, Saito H, Shiina S, Ikari T.    Clinical Evaluation of a Newly Developed Guidewire for Pancreatobiliary Endoscopy. J Clin Med. 2020 Dec 16;9(12):4059.  https://pubmed.ncbi.nlm.nih.gov/33339093/
  20. Hakuta R, Kogure H, Nakai Y, Kawakami H, Maguchi H, Mukai T, Iwashita T, Saito T, Togawa O, Matsubara S, Hayashi T, Maetani I, Ito Y, Hasebe O, Itoi T, Hanada K, Isayama H. Unilateral versus Bilateral Endoscopic Nasobiliary Drainage and Subsequent Metal Stent Placement for Unresectable Malignant Hilar Obstruction: A Multicenter Randomized Controlled Trial. J Clin Med. 2021 Jan 8;10(2):206. https://pubmed.ncbi.nlm.nih.gov/33430020/
  21. Naitoh I, Kamisawa T, Tanaka A, Nakazawa T, Kubota K, Takikawa H, Unno M, Masamune A, Kawa S, Nakamura S, Okazaki K; collaborators. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort. Dig Liver Dis. 2021 Oct;53(10):1308-1314. https://pubmed.ncbi.nlm.nih.gov/33664004/
  22. Saito T, Nakai Y, Mizuno S, Isayama H, Sasahira N, Kanai S, Noguchi K, Sato T, Ishigaki K, Hakuta R, Saito K, Hamada T, Takahara N, Kogure H, Koike K. Long-term outcome of endotherapy for pancreatic stones by using a dedicated pancreatic basket catheter. J Gastroenterol Hepatol. 2021 Sep;36(9):2424-2431. https://pubmed.ncbi.nlm.nih.gov/33675102/
  23. Watanabe T, Nakai Y, Mizuno S, Hamada T, Kogure H, Hirano K, Akamatsu N, Hasegawa K, Isayama H, Koike K. Prognosis of primary sclerosing cholangitis according to age of onset. J Hepatobiliary Pancreat Sci. 2021 Dec;28(12):1115-1120. https://pubmed.ncbi.nlm.nih.gov/33811469/
  24. Kawano F, Yoshioka R, Gyoda Y, Ichida H, Mizuno T, Ishii S, Fujisawa T, Imamura H, Mise Y, Isayama H, Saiura A. Laparoscopic cholecystectomy after endoscopic trans-papillary gallbladder stenting for acute cholecystitis: a pilot study of surgical feasibility. BMC Surg. 2021 Apr 7;21(1):184. https://pubmed.ncbi.nlm.nih.gov/33827521/
  25. Tomishima K, Ishii S, Fujisawa T, Ikemura M, Ushio M, Takahashi S, Yamagata W, Takasaki Y, Suzuki A, Ito K, Haga K, Ochiai K, Nomura O, Saito H, Shibuya T, Nagahara A, Isayama H. Evaluation of the Feasibility and Effectiveness of Placement of Fully Covered Self-Expandable Metallic Stents via Various Insertion Routes for Benign Biliary Strictures. J Clin Med. 2021 May 28;10(11):2397. https://pubmed.ncbi.nlm.nih.gov/34071678/
  26. Fujisawa T, Joshi BH, Takahashi S, Takasaki Y, Suzuki A, Ito K, Ochiai K, Tomishima K, Ishii S, Puri RK, Isayama H. IL-13Rα2 Is a Biomarker of Diagnosis and Therapeutic Response in Human Pancreatic Cancer. Diagnostics (Basel). 2021 Jun 23;11(7):1140. https://pubmed.ncbi.nlm.nih.gov/34201539/
  27. Kogure H, Kato H, Kawakubo K, Ishiwatari H, Katanuma A, Okabe Y, Ueki T, Ban T, Hanada K, Sugimori K, Nakai Y, Isayama H. A Prospective Multicenter Study of "Inside Stents" for Biliary Stricture: Multicenter Evolving Inside Stent Registry (MEISteR). J Clin Med. 2021 Jun 30;10(13):2936. https://pubmed.ncbi.nlm.nih.gov/34208969/
  28. Fujisawa T, Isayama H, Shibuya T, Tomishima K, Ishii S. Cholangioscopy and double-balloon enteroscopy mediated "sandwich puncture" of a completely closed choledochojejunostomy. VideoGIE. 2021 Jun 17;6(7):325-328. https://pubmed.ncbi.nlm.nih.gov/34278098/
  29. Ikemura M, Tomishima K, Ushio M, Takahashi S, Yamagata W, Takasaki Y, Suzuki A, Ito K, Ochiai K, Ishii S, Saito H, Fujisawa T, Nagahara A, Isayama H. Impact of the Coronavirus Disease-2019 Pandemic on Pancreaticobiliary Disease Detection and Treatment. J Clin Med. 2021 Sep 16;10(18):4177. https://pubmed.ncbi.nlm.nih.gov/34575288/
  30. Isayama H. Pancreato-biliary endoscopy: History of endoscopic biliary drainage. Dig Endosc. 2021 Nov 4. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/34738267/
  31. Yamashita Y, Tachikawa A, Shimokawa T, Yamazaki H, Itonaga M, Sakai Y, Sugiyama H, Nakai Y, Tanaka K, Isayama H, Kitano M. Covered versus uncovered metal stent for endoscopic drainage of a malignant distal biliary obstruction: a meta-analysis. Dig Endosc. 2022 Feb 3. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35114036/
  32. Akamatsu N, Hasegawa K, Egawa H, Ohdan H, Yoshizawa A, Kokudo N, Tazuma S, Tanaka A, Takikawa H. Donor age (≥45 years) and reduced immunosuppression are associated with the recurrent primary sclerosing cholangitis after liver transplantation - a multicenter retrospective study. Transpl Int. 2021 May;34(5):916-929. doi: 10.1111/tri.13852. Epub 2021 Mar 16. https://pubmed.ncbi.nlm.nih.gov/33629379/
  33. Watanabe T, Nakai Y, Mizuno S, Hamada T, Kogure H, Hirano K, Akamatsu N, Hasegawa K, Isayama H, Koike K. Prognosis of primary sclerosing cholangitis according to age of onset. J Hepatobiliary Pancreat Sci. 2021 Dec;28(12):1115-1120. doi: 10.1002/jhbp.952. Epub 2021 Apr 15. PMID: 33811469. https://pubmed.ncbi.nlm.nih.gov/33811469/
  34. Kametani T, Otani Y, Kanno K, Tazuma S. Erythromelalgic Symptoms in Left Subclavian Artery Stenosis. Intern Med. 2020 May 1;59(9):1235-1236. https://pubmed.ncbi.nlm.nih.gov/31956204/
  35. Nguyen PT, Kanno K, Pham QT, Kikuchi Y, Kakimoto M, Kobayashi T, Otani Y, Kishikawa N, Miyauchi M, Arihiro K, Ito M, Tazuma S. Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma. J Cancer Res Clin Oncol. 2020 Dec;146(12):3255-3268. https://pubmed.ncbi.nlm.nih.gov/32870388/
  36. Kobayashi T, Kanno K, Nguyen PT, Sugiyama A, Kawahara A, Otani Y, Kishikawa N, Ito M, Tazuma S. Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis. J Gastroenterol Hepatol. 2020 Dec;35(12):2140-2150. https://pubmed.ncbi.nlm.nih.gov/32365405/
  37. Nakazawa T, Kamisawa T, Okazaki K, Kawa S, Tazuma S, Nishino T, Inoue D, Naitoh I, Watanabe T, Notohara K, Kubota K, Ohara H, Tanaka A, Takikawa H, Masamune A, Unno M. Clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2020: (Revision of the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012). J Hepatobiliary Pancreat Sci. 2021 Mar;28(3):235-242. https://pubmed.ncbi.nlm.nih.gov/33586343/
  38. Yan Y, Naito T, Hsu NC, Shin DH, Kang HJ, Vidyarthi AR, Tazuma S, Hayashi J, Deshpande GA. Adoption of Hospitalist Care in Asia: Experiences From Singapore, Taiwan, Korea, and Japan. J Hosp Med. 2021 Jul;16(7):443-445. https://pubmed.ncbi.nlm.nih.gov/34197312/
  39. Akamatsu N, Hasegawa K, Egawa H, Ohdan H, Yoshizawa A, Kokudo N, Tazuma S, Tanaka A, Takikawa H. Donor age (≥45 years) and reduced immunosuppression are associated with the recurrent primary sclerosing cholangitis after liver transplantation - a multicenter retrospective study. Transpl Int. Transpl Int. 2021 May;34(5):916-929. https://pubmed.ncbi.nlm.nih.gov/33629379/
  40. Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S. Endoscopic approach in the diagnosis of high-grade pancreatic intraepithelial neoplasia. Dig Endosc. 2022 Jan 19. https://pubmed.ncbi.nlm.nih.gov/35165942/
  41. Hori Y, Chari ST, Tsuji Y, Takahashi N, Inoue D, Hart PA, Uehara T, Horibe M, Yamamoto S, Satou A, Zhang L, Notohara K, Naitoh I, Nakazawa T. Diagnosing Biliary Strictures: Distinguishing IgG4-Related Sclerosing Cholangitis From Cholangiocarcinoma and Primary Sclerosing Cholangitis. Mayo Clin Proc Innov Qual Outcomes. 2021 Jun 10;5(3):535-541. https://pubmed.ncbi.nlm.nih.gov/34195545/
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  43. Naitoh I, Kamisawa T, Tanaka A, Nakazawa T, Kubota K, Takikawa H, Unno M, Masamune A, Kawa S, Nakamura S, Okazaki K; collaborators. Pancreas and Biliary Tract Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort. Dig Liver Dis 2021 Oct;53(10):1308-1314. https://pubmed.ncbi.nlm.nih.gov/33664004/
  44. Nakazawa T, Kamisawa T, Okazaki K, Kawa S, Tazuma S, Nishino T, Inoue D, Naitoh I, Watanabe T, Notohara K, Kubota K, Ohara H, Tanaka A, Takikawa H, Masamune A, Unno M. Clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2020 (Revision of the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012). J Hepatobiliary Pancreat Sci. 2021 Mar;28(3):235-242. https://pubmed.ncbi.nlm.nih.gov/33586343/
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  46. Naito I, Nakazawa T. Endoscopic retrograde cholangiopancreatography and intraductal ultrasonography in the diagnosis of autoimmune pancreatitis and IgG4- related sclerosing cholangitis. J Med Ultrason (2001). 2021 Oct;48(4):573-580. https://pubmed.ncbi.nlm.nih.gov/34331625/
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  49. Ito T, Shimatani M, Masuda M, Nakamaru K, Mitsuyama T, Takaoka M, Naganuma M. Endoscopic retrieval of a migrated surgical clip in a choledochojejunal anastomosis using the rendezvous technique. Endoscopy. 2021 May 12. https://pubmed.ncbi.nlm.nih.gov/33979852/
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  54. Tokuhara M, Shimatani M, Mitsuyama T, Masuda M, Ito T, Miyamoto S, Fukata N, Miyoshi H, Ikeura T, Takaoka M, Kouda K, Okazaki K. Evaluation of complications after endoscopic retrograde cholangiopancreatography using a short type double balloon endoscope in patients with altered gastrointestinal anatomy: a single-center retrospective study of 1,576 procedures. J Gastroenterol Hepatol. 2020 Aug;35(8):1387-1396. https://pubmed.ncbi.nlm.nih.gov/32103516/
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